Our skin is an extraordinary organ. It's our body's first line of defense, protecting us from the outside world every single day.

I talk a lot about how the foods we eat can support our health from the inside out. But our skin is an organ we can also care for directly, and that's an important part of healthy aging.

And just like the rest of our body, our skin changes as we age.

Over time, we naturally produce less collagen and elastin, which help keep our skin strong, firm, and resilient. These changes can contribute to the fine lines, wrinkles, and loss of elasticity we associate with aging.

That's why I was interested in OneSkin, a longevity company that's studying the biology of skin aging. Their OS-01 FACE RICH CREAM is a product I use myself, and I want to share the science behind what makes it different.

It starts with an important question: Why does our skin produce less collagen and elastin as we age?

OneSkin's research centers on a fascinating biological process called cellular senescence, which is also an important area of longevity research.

Let me explain.

What's Happening Beneath Your Skin?

As we get older, some of our cells enter a state called senescence.

These cells stop dividing, but instead of being cleared away, some remain in our tissues, where they can release inflammatory substances that affect surrounding healthy cells.

Scientists sometimes call them "zombie cells."

And when these cells accumulate in your skin, they can contribute to changes in the very structures that keep your skin healthy and resilient.

I'm talking about:

  • Collagen, which gives your skin strength and firmness.

  • Elastin, which helps your skin stretch and bounce back.

  • Hyaluronic acid, which helps your skin retain moisture.

As these components decline, your skin can become thinner, drier, and less resilient.

And here's something particularly interesting.

During the first five years of menopause, women can lose up to 30% of their skin's collagen.¹

That's a significant change in a relatively short period of time.

But these changes aren't limited to women. Cellular aging affects everyone's skin.

The important takeaway is that the visible signs of skin aging reflect biological changes happening beneath the surface.

And here's what's exciting: scientists aren't just studying why our skin ages. They're also investigating whether targeting the biological processes behind aging can help support healthier, more resilient skin.

A Science-Backed Approach to Skin Health

OneSkin's scientists have spent more than a decade researching cellular aging and developed a proprietary peptide called OS-01, designed to target cellular senescence in the skin.

They've incorporated this peptide into OS-01 FACE RICH CREAM, combining it with ingredients that help support the skin's moisture barrier, hydration, and firmness as we age.

And OneSkin has studied its approach in both clinical and laboratory settings.

In a six-week, double-blind clinical study involving 29 adults ages 43–65, researchers reported that:²

  • 93% saw improved visible firmness.

  • 97% saw a reduced appearance of fine lines and wrinkles.

And in laboratory studies using skin tissue, OneSkin reported:³

  • 28% increase in measured collagen

  • 108% increase in a marker associated with elastin production

  • 77% increase in a marker associated with hyaluronic acid production

This is the kind of science-driven approach to skincare that interests me as a physician. And having used OS-01 FACE RICH CREAM myself, it's a product I'm happy to recommend to you.

A Special Offer for My Community

If you're interested in exploring this science-backed approach to skincare, OneSkin is offering my community an exclusive 15% discount on OS-01 FACE RICH CREAM with code DRLI.

Your discount will be automatically applied through the link and can be combined with subscription and bundle savings.

Wishing you health and happiness,

Dr. William Li